TREs, specifically homodimers on F2, we analyzed whether the increase of intracellular levels of RXR could be exert a selective modulator effect in each responsive element in response to T3.
On F2, this effect apparently occurs in an indirect form by TR sequestration in solution decreasing its availability to binding as homodimers in this responsive element.
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However, in Xenopus oocytes, in which RXR proteins are not detectable, the transactivation mediated by TRalpha1 and TRbeta1 is equivalent and independent of a RXR supply, raising the question of the identity of the thyroid hormone receptor partner in these cells.
In particular, interruption of different components of the chain of trafficking and metabolism has been associated with cancers arising in numerous organs of the body.
In contrast, the MBPTRE, which consists of an inverted palindrome formed by two hexamers spaced by 6 base pairs, confers an efficient transactivation by TRbeta1 but a poor transactivation by TRalpha1.
On the other hand, on TREpal the modulator effect would be by direct binding of heterodimers to DNA, or indirect by TR sequestration in solution, both due as this responsive element to be the preferential site to monomers binding.
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Nuclear receptors are metazoan transcription factors activated by small lipophilic ligands, such as steroid hormones, thyroid hormones, retinoids, vitamin D, or fatty acids.
NR4A receptors were shown to directly bind to and activate the promoter of the osteopontin gene (OPN) in osteoblastic cells, thus regulating its expression.
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TRs and SmRXR1 suggests that the invertebrate TR protein gained the ability to form a heterodimer with RXR.
In the present study, application of recombinant retinoic acid (RA) lowers retinoblastoma (RB) cell viability and ind.
